Biomaterial inks & Biomaterials based on Elastin
Biomaterial inks and biomaterials are printed layer-by-layer into 3-dimensional structures using bioprinting. They are ideally suited for applications in tissue engineering and research activities in the pharmaceutical and medical fields. With our unique material elastin, it is now possible for the first time to make elastin usable for bioprinting.
Basic materials
Our high-purity elastin hydrolysates are ideal base materials for developing your own biomaterial inks.
matripure® A, soluble high molecular weight hydrolyzed elastin
matripure® B, soluble low molecular weight hydrolyzed elastin
HIGHEST BIOACTIVITY THROUGH NATURAL RESOURCES
Our biomaterial inks are made from high quality natural resources to ensure the highest bioactivity. Like natural elastin, all elastin-based biomaterial inks contain post-translational modifications such as hydroxyproline and desmosine in native ratios.
Our new PEPTINEER-platform
Peptineer is a proprietary platform technology developed by matrihealth for innovative and advanced biomaterial design. With Peptineer, we introduce chemical modifications into peptides that lack amino acids with functionalizable side chains.
Peptineer enables chemical modifications of peptides regardless of the presence of amino acids with reactive side chains. This technology allows peptides composed primarily or exclusively of aliphatic, hydrophobic amino acids to be effectively engineered by introducing curable chemical entities at their termini.
Peptineer enables precise chemical modifications at the termini of peptides rich in hydrophobic amino acids. By artificially introducing reactive sites, curable chemical entities and other functional groups can be conjugated independent of amino acid side chain reactivity. Peptineer makes every peptide accessible for advanced functionalization, crosslinking, and material engineering.
Elastin is a highly relevant protein that naturally lacks amino acids with functionalizable side chains. With Peptineer technology, matrihealth overcomes these limitations, enabling the first-ever range of chemically functionalized elastin hydrolysates for advanced applications in tissue engineering, biomaterial design, and regenerative medicine.
matritrace-R, Rhodamine labeled Elastin
ELAMIN+ , Amino-enriched Elastin
Biomaterial inks
Elastin-based biomaterial inks for your research and development projects.
ELMA® - modified Elastin for 3D-Bioprinting
With ELMA®, matrihealth introduces for the first time an elastin methacrylate for advanced 3D bioprinting and tissue engineering. It enables a near-natural supplement for the production of an artificial extracellular matrix.
- Methacrylated elastin for bioprinting
- Important building protein of ECM
- Elastin available for bioprinting for the first time
- Ideal for printing tissues for tissue engineering
- Very good processability with all common bioprinters
- Excellent compatibility with gelatin and collagen
ELMA®+ - curable Elastin
ELMA®+ is a telechel based on elastin hydrolysate, featuring special functional groups that combine enhanced solubility with radical polymerization capability. Compared to ELMA®, it offers superior solubility and broader options for modulation. ELMA®+ dissolves readily at concentrations of 30% and higher and enables precise tuning of hydrogel properties after polymerization. Free carboxylic groups additionally allow targeted modifications, such as influencing cell responses or introducing secondary chemical crosslinking to fine-tune mechanical properties.
The shortage of donor organs and the body's immune response to implanted organs and tissues are leading to efforts to develop artificial tissues based on the body's own cells. One approach in this area of medical research, known as tissue engineering, is bioprinting. Bioprinting is an additive manufacturing process in which almost any geometric shape can be created by applying material in layers. In this process, the body's own cells are usually "printed" into a support structure made of biocompatible hydrogels, which gives the tissue its initial shape and is gradually replaced by cultured tissue. These hydrogels are usually made from cell-compatible materials such as collagen, alginate, gelatin, as well as specialty ceramics and biocompatible polymers, some of which are already found in natural tissue. Our elastin enables the production of biomaterial inks with an elastin content in appreciable quantities. This enables both the incorporation of elastin in the formation of new tissue and thus the production of naturally mimetic tissue, as well as the targeted adjustment of mechanical properties and improved replication of the extracellular matrix. The combination of the novel component elastin and the excellent properties of our biomaterial inks offer our customers many advantages and represent a unique selling point compared to products available on the market.
What is Bioprinting?
Tropoelastin
Tropoelastin is the soluble precursor of elastin and is produced biotechnologically. Our recombinant human tropoelastin isoform 2 (UniProt P15502-2) can be used for various applications in research and development:
- In tissue engineering as a scaffold material for growing tissues, e.g., skin, blood vessels, or lungs
- In biomaterial development
- In basic research as a model protein for investigating mechanisms of elastin formation, tissue aging, and matrix interactions.
Benefit from our many years of experience with biomaterial inks and contact us to jointly find the right materials and material combinations for your problems.
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